The results section outlines challenges hindering health information system interoperability in low and middle-income countries (LMICs), such as standardization gaps, fragmented systems, resource limitations, and data privacy concerns. Strategies proposed include standardization, consolidation, investment, capacity building, governance enhancement, collaboration fostering, usability prioritization, and continuous improvement initiatives. These strategies aim to address technical, organizational, financial, and cultural barriers, enabling LMICs to unlock the potential of health information systems for improved healthcare outcomes.